1492 Christopher Columbus discovered the island of Hispaniola in the Caribbean Sea.
1494 Christopher Columbus founded the city of Concepción de la Vega (Dominican Republic), on the island of Hispaniola.
1508 King Fernando granted the coat of arms to the city of Puerto Plata (island of Hispaniola), founded by Nicolás de Ovando in 1502.
1524 Francisco Hernández de Córdoba founded the city of Granada (Nicaragua), one of the first on the American mainland.
1534 Sebastián de Belalcázar founded the city of Quito (Ecuador), with the name of San Francisco de Quito.
1537 The Spanish captain Alonso de Cáceres founded the city of Comayagua, Honduras, in New Spain, with the name of villa de Sta Mª de la Concepción de Comayagua.
1540 The expedition of Alvar Núñez Cabeza de Vaca set sail from Cadiz for the Río de la Plata.
1541 Jorge Robledo founded the city of Santa Fe de Antioquia (Colombia) in the New Kingdom of Granada.
1545 Juan de Carvajal founded the city of El Tocuyo (Venezuela) in the province of Venezuela under the name of Nuestra Señora de la Pura y Limpia Concepción de El Tocuyo.
1548 The Spanish captain Alonso de Mercadillo founded the city of Loja, Ecuador, in the viceroyalty of Peru.
1659 The city of Paso del Norte was founded in New Spain and would later be divided into El Paso (United States) and Ciudad Juarez (Mexico).
1709 Jesuit Lucas Caballero founded the mission and town of Concepción (Chiquitos) in curent Bolivia.
1744 The city of Copiapó (Chile) was founded by Governor José Manso de Velasco, with the name of San Francisco de la Selva de Copiapó.
1833 Ana María de Soto, the first Spanish female marine, dies aged 58.
1999 The city of Vigan (Philippines), founded by Juan de Salcedo in 1572, is declared a World Heritage Site by UNESCO.
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