1451 Isabel I of Castile known, as "the Catholic", is born in Madrigal de las Altas Torres.
1483 Reconquista: Battle of Lucena in which King Boabdil is taken prisoner.
1503 Battle of Seminara between Spanish and French troops.
1513 Spanish pilot Antón de Alaminos discovers and documents the Gulf-stream.
1519 Hernán Cortés founds the city of Veracruz, Mexico.
1529 Spain and Portugal sign the Treaty of Saragossa, which will delimit exactly the areas of influence in Asia.
1535 Carlos I of Spain granted the coat of arms to the city of Tlaxcala, Mexico.
1569 Hernán Ruiz II, Spanish Renaissance architect. dies.
1572 Andrés Díaz Venero de Leyva founded the town of Guaduas (Colombia).
1578 Brunei becomes a vassal state of Spain.
1582 Francisco de Toledo, former Viceroy of Peru, dies.
1616 Spanish novelist, poet, playwright, and soldier Miguel de Cervantes dies.
1648 Pedro II of Portugal is born.
1672 Spanish comic actor Cosme Pérez ("Juan Rana") dies.
1692 Tomás de la Cerda Aragón, former viceroy of New Spain, dies.
1693 Painter Claudio Coello dies.
1702 The Marquis de la Ensenada was born.
1719 Felipe V created the Mossos d'Esquadra.
1741 Spanish troops break the siege of castle San Felipe in Cartagena de Indias (Colombia).
1758 Spanish military officer and politician Francisco Javier Castaños is born.
1779 Spanish navigator Francisco de Viedma y Narváez founded the cities of Viedma and Carmen de Patagones in Argentina.
1782 Spanish Governor Felipe de Neve founds SantaBarbara (California).
1819 The city of Cienfugos, Cuba, is founded.
1844 The Royal Order of Access to Historical Archives was promulgated.
1855 Queen Isabel II of Spain signs a law decreeing the creation of the first Spanish electrotelegraphic network.
1898 President Mckinley signed the Joint Resolution, an ultimatum to Spain, which would lead to the Spanish–American War.
1904 Philosopher María Zambrano is born in Vélez-Málaga.
1904 Philosopher and essayist María Zambrano is born in Vélez-Málaga.